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Distribution and localization of a G protein‐coupled inwardly rectifying K + channel in the rat
Author(s) -
Karschin Christine,
Schreibmayer Wolfgang,
Dascal Nathan,
Lester Henry,
Davidson Norman,
Karschin Andreas
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00590-7
Subject(s) - olfactory bulb , dentate gyrus , in situ hybridization , chemistry , brainstem , cerebellum , hippocampus , central nervous system , deep cerebellar nuclei , biophysics , inward rectifier potassium ion channel , neuroscience , g protein coupled inwardly rectifying potassium channel , anatomy , biology , microbiology and biotechnology , endocrinology , messenger rna , cerebellar cortex , ion channel , receptor , biochemistry , g protein , gene
The cellular distribution of the mRNA of the inwardly rectifying K + channel KGA (GIRK1) was investigated in rat tissue by in situ hybridization. KGA was originally cloned from the heart and represents the first G protein‐activated K + channel identified. It is expressed in peripheral tissue solely in the atrium, but not in the ventricle, skeletal muscle, lung and kidney. In the central nervous system KGA is most prominently expressed in the Ammon's horn and dentate gyrus of the hippocampus, neocortical layers II–VI, cerebellar granular layer, olfactory bulb, anterior pituitary, thalamic nuclei and several distinct nuclei of the lower brainstem. The abundant expression of KGA in many CNS neurons support its important role as a major target channel for G protein mediated receptor function.