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Presence of the brown fat‐specific mitochondrial uncoupling protein and iodothyronine 5'‐deiodinase activity in subcutaneous adipose tissue of neonatal lambs
Author(s) -
Trayhurn Paul,
Thomas Moira E.A.,
Duncan Jacqueline S.,
Nicol Fergus,
Arthur John R.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81115-g
Subject(s) - brown adipose tissue , adipose tissue , uncoupling protein , medicine , white adipose tissue , endocrinology , prdm16 , biology , thermogenin , thermogenesis , subcutaneous tissue , subcutaneous adipose tissue , iodothyronine deiodinase , deiodinase , thyroid , triiodothyronine , pathology
Subcutaneous adipose tissue of neonatal lambs has been examined for the presence of markers diagnostic of thermogenic brown fat. Uncoupling protein, uncoupling protein mRNA, and iodothyronine 5'‐deiodinase activity were each detected in subcutaneous adipose tissue, as well as in the major internal fat depot (perirenal), of newborn lambs. These brown fat markers were not present, however, in adipose tissue of adult sheep. It is concluded that subcutaneous fat in newborn lambs is functionally ‘brown’, and similar to the internal fat; subcutaneous and internal adipose tissues follow a similar developmental path ‐ from ‘brown’ to ‘white’.