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Production and characterization of monoclonal antibodies specific for different epitopes of human tenascin
Author(s) -
Balza Enrica,
Siri Annalisa,
Ponassi Marco,
Caocci Fabio,
Linnala Auli,
Virtanen Ismo,
Zardi Luciano
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80479-e
Subject(s) - monoclonal antibody , epitope , gene isoform , tenascin , microbiology and biotechnology , alternative splicing , epitope mapping , tenascin c , rna splicing , chemistry , antibody , biology , biochemistry , immunology , gene , cell , extracellular matrix , fibronectin , rna
We have obtained and characterized 11 monoclonal antibodies (mAbs) specific for different domains of human tenascin (TN). Five of these mAbs reacted with epitopes contained in the TN area that undergoes alternative splicing and are thus able to recognize specific TN isoforms. These mAbs are a useful tool to study the expression and distribution of TN and its different isoforms in normal and pathological tissues.