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Identification of putative internalization signals in prion proteins
Author(s) -
Kazim A.Latif
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80285-3
Subject(s) - internalization , endocytosis , cytoplasm , prion proteins , prion protein , microbiology and biotechnology , membrane protein , identification (biology) , biology , chemistry , biochemistry , membrane , cell , medicine , botany , disease , pathology
Prion proteins were found to contain regions in their cytoplasmic domains that have significant structural homologies to molecular trafficking signals for internalization of membrane proteins. These regions may facilitate the endocytosis of prion proteins, which appears to be a first step in their conversion to the abnormal, amyloidogenic form.
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