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Dextran protection of erythrocytes from low‐pH‐induced hemolysis
Author(s) -
Cudd Amelia,
Arvinte Tudor,
Schulz Barbara,
Nicolau Claude
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80741-0
Subject(s) - hemolysis , dextran , chemistry , biochemistry , biology , immunology
Low‐pH‐induced hemolysis of erythrocytes is inhibited by dextrans. The protective effect was observed with dextrans larger than 40 kDa. Electron microscopy showed dextrans of 150 kDa in a tight association with the erythrocyte membrane. These results indicate that dextrans stop the low‐pH‐induced hemolysis by interacting with the acid‐induced defects in the erythrocyte membrane [(1989) Biochim. Biophys. Acta, in press.
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