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Stereospecific bioactions of 5‐hydroxyicosatetraenoate
Author(s) -
Rossi Adriano G.,
Thomas Michael J.,
O'Flaherty Joseph T.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80360-0
Subject(s) - stereospecificity , degranulation , arachidonic acid , chemistry , metabolite , cytosol , platelet activating factor , platelet , receptor , biochemistry , biology , immunology , enzyme , catalysis
5( S )‐Hydroxyicosatetraenoate stimulates human polymorphonuclear neutrophils (PMNs) to raise their cytosolic calcium. It also potentiates the cells' degranulation responses to platelet‐activating factor and diacylglycerols. We synthesized 5( R )‐hydroxyicosatetraenoate and found it to be 20–100‐fold weaker than the natural isomer in these assays. Thus, the arachidonic acid metabolite activates PMNs by a stereospecific possibly receptor‐mediated mechanism.

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