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Effect of truncated glucagon‐like peptide 1 on cAMP in rat gastric glands and HGT‐1 human gastric cancer cells
Author(s) -
Hansen A.B.,
Gespach C.P.,
Rosselin G.E.,
Holst J.J.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80297-7
Subject(s) - secretion , glucagon , gastric acid , medicine , endocrinology , glucagon like peptide 1 , peptide , biology , cancer , enterochromaffin like cell , cancer cell , gastric glands , gastric mucosa , chemistry , stomach , biochemistry , hormone , type 2 diabetes , diabetes mellitus
We tested the truncated 7–37 glucagon‐like peptide 1 (TGLP‐1), a naturally occurring porcine intestinal peptide, and other members of the glucagon family, including pancreatic glucagon (G‐29), GLP‐1 and GLP‐2 for their ability to activate the cAMP generating system in rat gastric glands and HGT‐1 human gastric cancer cells. In rat fundic glands, TGLP‐1 was about 100 times more potent (EC 50 = 2.8 × 10 −9 M) than GLP‐1 of G‐29, and 10 times more potent than G‐29 in the HGT‐1 cell line. Our results support the notion that TGLP‐1 plays a direct role in the regulation of acid secretion in rat and human gastric mucosa.
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