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The calcitonin‐like sequence of the β CGRP gene
Author(s) -
Alevizaki Maria,
Shiraishi Akio,
Rassool Feyruz V.,
Ferner Gwendolynn J.M.,
Maclntyre Iain,
Legon Steve
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)81338-2
Subject(s) - calcitonin gene related peptide , calcitonin , gene , gene duplication , sequence (biology) , genetics , biology , peptide sequence , endocrinology , neuropeptide , receptor
We have identified a region within the β CGRP gene which has the potential to encode a novel calcitonin‐like peptide. The gene is located on the short arm of chromosome 11 (11p 12–14.2) and we suggest that it resulted from a local duplication of the α gene. We have been unable to detect the corresponding mRNA in a variety of tissues which express α‐calcitonin. It is not clear whether this sequence can be expressed in man.