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Norepinephrine with its precursors and their antagonists haloperidol and phentolamine interact with dye free radicals in opposite ways
Author(s) -
Marinov B.S.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)81198-x
Subject(s) - phentolamine , chemistry , norepinephrine , haloperidol , radical , electron acceptor , tyrosine , photochemistry , dopamine , medicine , organic chemistry , biochemistry , receptor
In the reactions with dye free radicals, catecholamines exhibited reversible electron donor and acceptor properties with the effectiveness increasing from tyrosine to norepinephrine. The physiological antagonists haloperidol and phentolamine showed opposite patterns of behaviour in the same reactions, changing their properties as acceptors to electron donors. The regularity observed is similar to that demonstrated earlier by a variety of Na + and Ca 2+ channel modulators.