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Molecular mechanisms regulating the synthesis of transferrin receptors and ferritin in human erythroleukemic cell lines
Author(s) -
Louache F.,
Pelosi E.,
Titeux M.,
Peschle C.,
Testa U.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80781-x
Subject(s) - transferrin , ferritin , transferrin receptor , receptor , biochemistry , chemistry , cell culture , biosynthesis , protein biosynthesis , biology , gene , genetics
The effects of either iron salts or iron chelators on the biosynthesis of transferrin receptors in human erythroleukemic lines was investigated. Addition of these compounds induced a rapid and marked decrease (iron salts) or increase (iron chelators) in the level of transferrin receptors synthesis. Both phenomena were inhibited by actinomycin D. In contrast, the increase in the synthesis of ferritin induced in these cells by addition of iron salts was not inhibited by actinomycin D. These results suggest that iron salts modulate the synthesis of transferrin receptors and ferritin via different molecular mechanisms, of transcriptional and translation type, respectively.