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Distribution of progesterone‐binding cytochrome P450 and steroid‐17α‐hydroxylase/C‐17,20‐lyase within different compartments of the rat testis
Author(s) -
Kühn-Velten Nikolaus,
Staib Wolfgang
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80877-1
Subject(s) - leydig cell , cytochrome p450 , endocrinology , medicine , compartment (ship) , steroid , biology , hydroxylation , chemistry , cytochrome , enzyme , metabolism , biochemistry , hormone , oceanography , geology , luteinizing hormone
Progesterone‐binding capacity of cytochrome P450 and rate of progesterone consumption by cytochrome P450‐dependent hydroxylases are highest in the Leydig cell fraction but are also detectable in the non‐Leydig cell fraction of interstitial cells as well as in seminiferous tubules from rat testis. The Leydig cell compartment, however, contributes only to a minor extent to the total progesterone binding and hydroxylation within the whole testis.