Open AccessSARS-CoV2 vertical transmission with adverse effects on the newborn revealed through integrated immunohistochemical, electron microscopy and molecular analyses of Placenta
Author(s) -
Fabio Facchetti,
Mattia Bugatti,
Emma Drera,
Claudio Tripodo,
Enrico Sartori,
Valeria Cancila,
Marta Papaccio,
R. Castellani,
Stefano Casola,
María Beatrice Boniotti,
Patrizia Cavadini,
Antonio Lavazza
Publication year - 2020
Publication title -
ebiomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.596
H-Index - 63
ISSN - 2352-3964
DOI - 10.1016/j.ebiom.2020.102951
Subject(s) - placenta , syncytiotrophoblast , intervillous space , in situ hybridization , virology , immunohistochemistry , immunostaining , biology , coronavirus , pathology , immunofluorescence , fetus , immunology , medicine , andrology , microbiology and biotechnology , antibody , covid-19 , pregnancy , messenger rna , gene , disease , genetics , biochemistry , infectious disease (medical specialty)
We provide first-time evidence for maternal-fetal transmission of SARS-CoV-2, likely propagated by circulating virus-infected fetal mononuclear cells. Placenta infection was associated with recruitment of maternal inflammatory cells in the intervillous space, without villitis. PD-L1 expression in syncytiotrophoblast and Hofbaeur cells, together with limited production of NETs, may have prevented immune cell-driven placental damage, ensuring sufficient maternal-fetus nutrient exchanges.
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