Noninvasive Pulse Waveform Analysis in Clinical Trials: Similarity of Two Methods for Calculating Aortic Systolic Pressure

Concerns persist about the validity of generalized transfer function-derived, aortic blood-pressure measurements during the administration of vasoactive agents in clinical trials. Hence, we compared this transfer-function method with another, which estimates aortic systolic pressure directly from the late systolic shoulder of the radial pressure wave, after administration of placebo, ramipril, or atenolol.