Open AccessAn Update on Targets for Treating Osteoarthritis Pain: NGF and TRPV1
Author(s) -
A. Obeidat,
Anita Donner,
Rachel E. Miller
Publication year - 2020
Publication title -
current treatment options in rheumatology
Language(s) - English
Resource type - Journals
ISSN - 2198-6002
DOI - 10.1007/s40674-020-00146-x
Subject(s) - trpv1 , osteoarthritis , medicine , physical medicine and rehabilitation , neuroscience , physical therapy , psychology , alternative medicine , pathology , receptor , transient receptor potential channel
a)Osteoarthritis (OA) is the most common form of arthritis, and pain is the primary symptom of the disease, yet analgesic options for treating OA pain remain limited. In this review, we aimed to give an update on the current clinical and preclinical studies targeting two pathways that are being investigated for treating OA pain: the nerve growth factor (NGF) pathway and the transient receptor potential vanilloid-1 (TRPV1) pathway.