Open AccessCAR-Tregs as a Strategy for Inducing Graft Tolerance
Author(s) -
Johanna Wagner,
Qizhi Tang
Publication year - 2020
Publication title -
current transplantation reports
Language(s) - English
Resource type - Journals
ISSN - 2196-3029
DOI - 10.1007/s40472-020-00285-z
Subject(s) - medicine , chimeric antigen receptor , immunology , human leukocyte antigen , adoptive cell transfer , transplantation , antigen , organ transplantation , humanized mouse , immunotherapy , t cell , immune system
The adoptive transfer of alloantigen-specific regulatory T cells (Tregs) following organ transplantation is an emerging treatment paradigm that may induce tolerance and reduce the risk for graft rejection. In particular, redirecting Treg specificity via expression of synthetic chimeric antigen receptors (CARs) has demonstrated therapeutic promise in several preclinical studies. In this review, we highlight recent progress and remaining barriers to the clinical translation of CAR-Treg therapies.