Open AccessOvarian Tissue Cryopreservation and Novel Bioengineering Approaches for Fertility Preservation
Author(s) -
Andrea Jones,
Ariella Shikanov
Publication year - 2020
Publication title -
current breast cancer reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.467
H-Index - 18
eISSN - 1943-4596
pISSN - 1943-4588
DOI - 10.1007/s12609-020-00390-z
Subject(s) - ovarian tissue cryopreservation , fertility preservation , cryopreservation , ovarian follicle , andrology , vitrification , ovarian tissue , embryo cryopreservation , in vitro maturation , biology , medicine , fertility , ovary , embryo , oocyte , microbiology and biotechnology , population , environmental health
Breast cancer patients who cannot delay treatment or for whom hormone stimulation and egg retrieval are contraindicated require alternative methods of fertility preservation prior to gonadotoxic treatment. Ovarian tissue cryopreservation is an alternative approach that may offer patients the opportunity to preserve fertility and carry biologically-related children later in life. Various experimental approaches are being explored to obtain mature gametes from cryopreserved and thawed ovarian tissue for fertilization and implantation using biomimetic tissue culture in vitro. Here we review the most recent developments in ovarian tissue cryopreservation and exciting advances in bioengineering approaches to in vitro tissue and ovarian follicle culture.