Backbone and side-chain chemical shift assignments of p50 subunit of NF-κB transcription factor | Zendy

Amrinder Singh | Zendy; H. Jane Dyson | Zendy

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Backbone and side-chain chemical shift assignments of p50 subunit of NF-κB transcription factor

Author(s) -

Amrinder Singh,

H. Jane Dyson

Publication year - 2020

Publication title -

biomolecular nmr assignments

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.359

H-Index - 16

eISSN - 1874-2718

pISSN - 1874-270X

DOI - 10.1007/s12104-020-09978-z

Subject(s) - transcription factor , enhancer , p50 , protein subunit , transcription (linguistics) , dna , chemistry , promoter , genetics , electrophoretic mobility shift assay , gene , side chain , microbiology and biotechnology , biology , gene expression , linguistics , philosophy , organic chemistry , polymer

Nuclear Factor κB (NF-κB) is a family of five related transcription factors that recognize a κB DNA element on the promoter and enhancer regions of target genes and modulate their expression. Here we report a complete set of 1 H, 13 C, 15 N backbone and side chain resonance assignments for the p50 DNA binding and dimerization domains of the p50 homodimer form of the NF-κB transcription factor. The chemical shift data constitute a first step towards understanding the mechanism of interaction of the p50 homodimer with DNA.

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