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Effect of medium‐chain fatty acid positional distribution in dietary triacylglycerol on lymphatic lipid transport and chylomicron composition in rats
Author(s) -
Carvajal Octavio,
Nakayama Masahiro,
Kishi Taiji,
Sato Masao,
Ikeda Ikuo,
Sugano Michihiro,
Imaizumi Katsumi
Publication year - 2000
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-000-0651-6
Subject(s) - chylomicron , interesterified fat , chemistry , lymph , linoleic acid , lipidology , fatty acid , clinical chemistry , food science , biochemistry , lipoprotein , very low density lipoprotein , cholesterol , lipase , pathology , medicine , enzyme
The present study was carried out to examine if the positional distribution of medium‐chain fatty acid (MCF) in dietary synthetic fat influences lymphatic transport of dietary fat and the chemical composition of chylomicrons in rats with permanent cannulation of thoracic duct. Four types of synthetic triacylglycerol were prepared: (i) sn ‐1(3) MCF‐ sn 2 linoleic acid, (ii) interesterified sn ‐1(3) MCF‐ sn 2 linoleic acid, (iii) sn ‐2 MCF‐ sn ‐1(3) linoleic acid, and (iv) interesterified sn ‐2 MCF‐ sn ‐1(3) linoleic acid. A purified diet composed of equal amounts of the synthetic fat and cocoa butter was given to rats with permanent lymph duct cannulation. The positional distribution of MCF in the dietary fat had no significant effect on the lymph flow, triacylglycerol output, phospholipid output, lipid composition of chylomicrons, or the particle size. The positional distribution of MCF in the synthetic triacylglycerol was maintained in the chylomicron triacylglycerol. These results showed that MCF in the dietary triacylglycerol is transported into lymphatics and the positional distribution is well preserved in chylomicron triacylglycerol.