Premium
Biosafety Evaluation of Three Sodium Lauryl N ‐Amino Acids Synthesized from Silk Industrial Waste in Mice
Author(s) -
Ding Biao,
Wan LiangZe,
Zhang YuQing
Publication year - 2017
Publication title -
journal of surfactants and detergents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.349
H-Index - 48
eISSN - 1558-9293
pISSN - 1097-3958
DOI - 10.1007/s11743-017-1995-z
Subject(s) - sericin , chemistry , pulmonary surfactant , fibroin , silk , sodium , bombyx mori , antioxidant , food science , amino acid , biochemistry , nuclear chemistry , organic chemistry , computer science , gene , operating system
Abstract In this study, three amino acid mixtures recovered from silk industry waste were reacted with lauryl chloride to synthesize three sodium laurel N ‐amino acid surfactants. The three types of anionic surfactants are referred to as silk fibroin surfactant, silk sericin surfactant, and silkworm pupae surfactant. All three surfactants showed good surface properties. To evaluate biological safety, we added these three surfactants to the normal diet of mice for 8 weeks. Blood indices, blood lipid, antioxidant capacity (GSH‐PX, MDA, T‐AOC, and T‐SOD), and lipid metabolism key enzyme mRNA (PPAR‐γ, SREBP, FASN, and C/EBP‐α) levels in the liver were measured. No evident histopathological changes were found in the liver and kidney. The results showed no significant difference in their indexes between the surfactant‐fed and normal diet‐fed mice. Thus, the three amino acid surfactants are biologically safe and can be used in daily chemical cleaning products. These surfactants will not only help to reduce wastage of resources and damage to the environment, but also yield economic benefits to the silk industry in the future.