Open AccessThe effect of a novel LRRC6 mutation on the flagellar ultrastructure in a primary ciliary dyskinesia patient
Author(s) -
Yaqian Li,
Chuan Jiang,
Xueguang Zhang,
Mohan Liu,
Yongkang Sun,
Yihong Yang,
Ying Shen
Publication year - 2021
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-020-02036-6
Subject(s) - primary ciliary dyskinesia , asthenozoospermia , male infertility , biology , sperm motility , infertility , cilium , dynein , motile cilium , intracytoplasmic sperm injection , mutation , situs inversus , genetics , sperm , andrology , medicine , gene , anatomy , pregnancy , microtubule , bronchiectasis , lung
There are limited genes known to cause primary ciliary dyskinesia (PCD)-associated asthenozoospermia. In the present study, we aimed to expand the spectrum of mutations in PCD and to provide new information for genetic counseling diagnoses and the treatment of male infertility in PCD.