Open AccessAssociation between miR-146a C > G, miR-149 T > C, miR-196a2 T > C, and miR-499 A > G polymorphisms and susceptibility to idiopathic recurrent pregnancy loss
Author(s) -
Meysam Alipour,
Maryam Abtin,
Ali Hosseinzadeh,
Masoud Maleki
Publication year - 2019
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-019-01573-z
Subject(s) - genotyping , genotype , allele , miscarriage , genetic predisposition , restriction fragment length polymorphism , pregnancy , medicine , microrna , biology , gastroenterology , immunology , genetics , gene , disease
A growing body of evidence suggests that microRNAs play fundamental regulatory roles in embryo implantation and maintenance of pregnancy. The aim of this study was to investigate the possible association between miR-146a C > G, miR-149 T > C, miR-196a2 T > C, and miR-499 A > G polymorphisms and genetic susceptibility to recurrent pregnancy loss (RPL).