Synthesis of spin‐labeled neutral lipids: Nitroxyl derivatives of triglycerides and sterol esters | Zendy

Morrisett Joel D. | Zendy

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Synthesis of spin‐labeled neutral lipids: Nitroxyl derivatives of triglycerides and sterol esters

Author(s) -

Morrisett Joel D.

Publication year - 1974

Publication title -

lipids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 120

eISSN - 1558-9307

pISSN - 0024-4201

DOI - 10.1007/bf02532183

Subject(s) - stearic acid , chemistry , nitroxyl , acyl group , organic chemistry , acylation , fatty acid , steroid , sterol , triglyceride , cholesteryl ester , derivative (finance) , trifluoroacetic anhydride , cholesterol , biochemistry , group (periodic table) , catalysis , lipoprotein , hormone , financial economics , economics

Methods for the preparation of useful spin‐labeled neutral lipids are described. A spin‐labeled triglyceride has been prepared by acylation of 1,3‐distearoylglycerol with stearic acid anhydride bearing the 4′,4′‐dimethyloxazolidine‐N‐oxyl ring at carbon‐12. The same fatty acid anhydride has been used to acylate the 3‐hydroxy group of cholesterol to obtain a cholesteryl ester with the nitroxyl function in the fatty acyl chain. The 4′,4′‐dimethyloxazolidinyl‐1‐oxyl derivative of 5α‐an drostan‐3‐one‐17β‐ol has been esterified with stearic acid anhydride to obtain a steroid ester with the paramagnetic center in the steroid nucleus.

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