Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo | Zendy

Kosuke Inoue | Zendy; Hitoshi Kuwana | Zendy; Yoshiko Shimamura | Zendy; Koji Ogata | Zendy; Yoshinori Taniguchi | Zendy; Toru Kagawa | Zendy; Taro Horino | Zendy; Toshihiro Takao | Zendy; Tatsuhito Morita | Zendy; Sei Sasaki | Zendy; Noboru Mizushima | Zendy; Yoshio Terada | Zendy

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Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo

Author(s) -

Kosuke Inoue,

Hitoshi Kuwana,

Yoshiko Shimamura,

Koji Ogata,

Yoshinori Taniguchi,

Toru Kagawa,

Taro Horino,

Toshihiro Takao,

Tatsuhito Morita,

Sei Sasaki,

Noboru Mizushima,

Yoshio Terada

Publication year - 2009

Publication title -

clinical and experimental nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.765

H-Index - 50

eISSN - 1437-7799

pISSN - 1342-1751

DOI - 10.1007/s10157-009-0254-7

Subject(s) - medicine , cisplatin , in vivo , nephrology , apoptosis , autophagy , cancer research , microbiology and biotechnology , pathology , urology , pharmacology , oncology , chemotherapy , biochemistry , biology , genetics

Autophagy is an intracellular bulk degradation process induced by cell starvation. Autophagy was recently reported to be induced by various stresses such as hypoxia, ischemia/reperfusion, toxins, and denatured proteins, and to affect cell survival and death. Light chain 3-II (LC3-II) is specifically located on double membrane-bound autophagosomes that envelop disused proteins or organelles.

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