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The chemistry and biological function of natural marine toxins
Author(s) -
Yasumoto Takeshi
Publication year - 2001
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.1010
Subject(s) - ciguatoxin , marine toxin , chemistry , ciguatera , natural product , fish <actinopterygii> , stereochemistry , reagent , organic chemistry , toxin , biology , biochemistry , fishery
Studies on ciguatera fish poisoning led to clarification of the absolute stereochemistry of ciguatoxin, gambierol, gambieric acids, and maitotoxin. Anisotropic NMR reagents and fluorometric chiral HPLC reagents were effectively used together with synthesis of partial structures. Structures of 16 ciguatoxin congeners were successfully elucidated by FAB/MS/MS using samples of 5 μg or less. Stereochemical assignments were also achieved on dinophysistoxin‐1, pectenotoxins, yessotoxins, polycavernoside‐A, azaspiracid, and prymnesins. The toxins possessed poly‐cyclic‐ether structures and originated from unicellular algae. Biological functions are briefly described. © 2000 John Wiley & Sons, Inc. and The Japan Chemical Journal Forum Chem Rec 1:228–242, 2001
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