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Tumor Targeting: A Strategy for Tumor Targeting by Higher‐Order Glycan Pattern Recognition: Synthesis and In Vitro and In Vivo Properties of Glycoalbumins Conjugated with Four Different N ‐Glycan Molecules (Small 46/2020)
Author(s) -
Smirnov Ivan,
Sibgatullina Regina,
Urano Sayaka,
Tahara Tsuyoshi,
Ahmadi Peni,
Watanabe Yasuyoshi,
Pradipta Ambara R.,
Kurbangalieva Almira,
Tanaka Katsunori
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202070253
Subject(s) - glycan , in vivo , in vitro , conjugated system , click chemistry , cancer research , microbiology and biotechnology , chemistry , computational biology , biophysics , nanotechnology , combinatorial chemistry , biochemistry , materials science , biology , glycoprotein , organic chemistry , polymer
In article number 2004831, Almira Kurbangalieva, Katsunori Tanaka, and co‐workers successfully apply the glycan pattern recognition mechanisms for developing a promising cancer targeting strategy in both cell‐ and mouse‐based experiments. The use of the very fast, selective and effective RIKEN click reaction allows to synthesize and screen various structurally well‐defined glycoalbumins containing four different N‐glycan structures in a very short time, as novel diagnostic, prophylactic, and therapeutic agents.
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