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Diabetes Treatment: Cold‐Responsive Nanocapsules Enable the Sole‐Cryoprotectant‐Trehalose Cryopreservation of β Cell–Laden Hydrogels for Diabetes Treatment (Small 50/2019)
Author(s) -
Cheng Yue,
Yu Yunru,
Zhang Yuntian,
Zhao Gang,
Zhao Yuanjin
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201970269
Subject(s) - cryoprotectant , cryopreservation , trehalose , nanocapsules , self healing hydrogels , viability assay , glycerol , diabetes mellitus , cell , chemistry , materials science , microbiology and biotechnology , medicine , nanotechnology , biochemistry , polymer chemistry , biology , endocrinology , embryo , nanoparticle
In article number 1904290, Gang Zhao, Yuanjin Zhao, and co‐workers propose a novel cryopreservation method for β cells by combining cold‐responsive nanocapsules and alginate hydrogel encapsulation. Great cell viability is obtained without using any toxic cryoprotectant and the cryopreserved β cell‐laden hydrogels can be transplanted into diabetic rats for blood glucose regulation.
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