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Catalytically Selective Chemotherapy from Tumor‐Metabolic Generated Lactic Acid
Author(s) -
Tian Zhimin,
Yang Kaili,
Yao Tianzhu,
Li Xuhui,
Ma Yuanyuan,
Qu Chaoyi,
Qu Xiaoli,
Xu Yujing,
Guo Yinhui,
Qu Yongquan
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201903746
Subject(s) - catalysis , lactic acid , tumor microenvironment , chemistry , metabolism , chemotherapy , oxidase test , biochemistry , glucose oxidase , enzyme , cancer research , apoptosis , peroxidase , tumor cells , combinatorial chemistry , biology , bacteria , genetics
Lactic acid (LA) is a powerful molecule as the metabolic driver in tumor microenvironments (TMEs). Inspired by its high intratumoral level (5–20 µmol g −1 ), a novel treatment paradigm via the cascade release of H 2 O 2 and ·OH from the LA generated by tumor metabolism is developed for catalytic and pH‐dependent selective tumor chemotherapy. By utilizing the acidity and overexpression of LA within the TME, the constructed lactate oxidase (LOD)‐immobilized Ce‐benzenetricarboxylic acid (Ce‐BTC) metal organic framework enables the intratumoral generation of ·OH via a cascade reaction: 1) the in situ catalytic release of H 2 O 2 from LA by LOD, and 2) the catalytic production of ·OH from H 2 O 2 by Ce‐BTC with peroxidase‐like activity. Highly toxic ·OH effectively induces tumor apoptosis/death. A new strategy for selective tumor chemotherapy is provided herein.
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