Investigation of Photostability of Istradefylline Aqueous Solution | Zendy

Xu Haojie | Zendy; Wang Yiyun | Zendy; Wang Hongyi | Zendy; Zheng Zhonghui | Zendy; Meng Zihui | Zendy; Xue Min | Zendy; Xu Zhibin | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Investigation of Photostability of Istradefylline Aqueous Solution

Author(s) -

Xu Haojie,

Wang Yiyun,

Wang Hongyi,

Zheng Zhonghui,

Meng Zihui,

Xue Min,

Xu Zhibin

Publication year - 2020

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201904148

Subject(s) - medicine , aqueous solution , chemistry

Istradefylline is a selective adenosine antagonist for A2a receptor, and it is used to treat Parkinson's syndrome and improve dyskinesia in the early stage of Parkinson's disease. Istradefylline aqueous solution were preserved in darkness and light respectively, and it was found that Istradefylline aqueous solution were extremely unstable in light. An impurity of Istradefylline was identified by HPLC and further collected by preparative HPLC. The impurity was characterized by NMR and MS and identified as Z‐Istradefylline, a photo degradation product of Istradefylline. The founding of degradation phenomenon makes the research on the stability of Istradefylline aqueous solution absolutely necessary for the quality control of the drug.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research