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Synthesis, Characterization and Biocompatibility of Mesolamellar Calcium Phosphate Hybrids Prepared by Anionic Surfactant Templating
Author(s) -
Salinas Antonio J.,
BlancoBécares José M.,
Mersinlioglu Okan,
Casarrubios Laura,
FernándezVilla Daniel,
Feito María J.,
Portolés Teresa,
González Blanca,
ValletRegí María
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201703130
Subject(s) - brushite , biocompatibility , dodecylbenzene , pulmonary surfactant , lamellar structure , apatite , chemical engineering , hybrid material , phosphate , sulfonate , aqueous solution , calcium , fluorapatite , mesophase , materials science , chemistry , sodium , nuclear chemistry , organic chemistry , engineering , composite material , phase (matter)
Abstract Calcium phosphate (CaP) based hybrid materials have been synthesized through a precipitation method in aqueous medium in the presence of the anionic surfactant sodium dodecylbenzene sulfonate (SDBS) as structure directing agent. Parameters of synthesis, such as Ca/P molar ratio, surfactant concentration and initial pH, have been investigated trying to get mesostructured CaP phases. A lamellar‐like hybrid mesophase consisting in several wavy layers of apatite or apatite‐brushite nanoplates was successfully obtained. Materials have been characterized by several physico‐chemical techniques. A potential application of these lamellar calcium phosphate based hybrids can be as matrixes in drug delivery systems with the possibility of loading hydrophobic drugs in the organic interlayers. To evaluate their potential as biomaterials, the biocompatibility of two hybrids has been studied in vitro with human Saos‐2 osteoblasts. Cell assays showed that, upon the appropriate synthesis and stabilization conditions, a biocompatible CaP and SDBS mesolamellar hybrid can be prepared.