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Tandem mass spectrometric analysis of glyphosate, glufosinate, aminomethylphosphonic acid and methylphosphinicopropionic acid
Author(s) -
Goodwin Lee,
Startin James R.,
Goodall David M.,
Keely Brendan J.
Publication year - 2003
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1007
Subject(s) - chemistry , aminomethylphosphonic acid , glufosinate , tandem mass spectrometry , analyte , mass spectrometry , electrospray , ion , ion trap , fragmentation (computing) , phosphinate , chromatography , tandem , analytical chemistry (journal) , glyphosate , organic chemistry , metabolite , biochemistry , materials science , fire retardant , computer science , agronomy , composite material , biology , operating system
Abstract A detailed MS n study of glyphosate, glufosinate and their main metabolites, aminomethylphosphonic acid and methylphosphinicopropionic acid, using an ion trap mass spectrometer, was performed. The analytes show good response in negative ion electrospray mass spectrometry (ES‐MS) as [MH] − ions. Tandem‐MS spectra reveal a wealth of structurally specific ions, allowing characterisation of the fragmentation pathways of the four analytes in their native form for the first time. The ions formed at each stage of fragmentation reveal ions common to each analyte, such as phosphinate, as well as analyte specific transitions. Simplex optimisation allows optimum trapping and fragmentation parameters to be determined leading to improved response for particular transitions and transition sequences, and revealing previously unseen ions. Copyright © 2003 John Wiley & Sons, Ltd.