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Anti‐acne properties of hydrophobic fraction of red ginseng ( Panax ginseng C.A. Meyer) and its active components
Author(s) -
Hou Joon Hyuk,
Shin Hyunjung,
Jang Kyoung Hwa,
Park Chae Kyu,
Koo Bonsuk,
Shin Hyeji,
Yuk Soon Hong,
Lee Ki Yong
Publication year - 2019
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6243
Subject(s) - ginseng , propionibacterium acnes , antimicrobial , acne , traditional medicine , benzoyl peroxide , chemistry , azelaic acid , antibiotics , antibacterial activity , food science , medicine , bacteria , biology , biochemistry , organic chemistry , dermatology , alternative medicine , pathology , polymerization , polymer , genetics
Acne is a chronic inflammatory disease of the skin that occurs when bacteria abnormally grow in hair follicles. The most common treatment is antibiotics, but they are limited due to antibiotic resistance. The purpose of this study was to identify the active ingredients of the antimicrobial effects of red ginseng ( Panax ginseng C.A. Meyer), compare it to existing antibacterial substances, and determine its potential efficacy as a natural drug product. The hydrophobic fraction in red ginseng ethanol extract (RGEF) showed the same or better antimicrobial activity against Propionibacterium acnes than benzoyl peroxide or azelaic acid. In addition, the antimicrobial component derived from red ginseng selectively showed a high antimicrobial effect on P. acnes . Nuclear magnetic resonance spectroscopic analysis showed that the active antimicrobial substance in this fraction was panaxynol and panaxydol. Twenty subjects who had acne symptoms were treated with cream containing 3 mg/g of RGEF for 4 weeks. It was found that oxidized sebum contents and redness of the skin were reduced, and symptoms of the early to middle stage of acne were effectively improved. This study showed that red ginseng extract containing panaxynol and panaxydol can effectively control the symptoms of acne.