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Evaluation of antipyretic potential of Vernonia cinerea extract in rats
Author(s) -
Gupta Malaya,
Mazumder U. K.,
Manikandan L.,
Bhattacharya S.,
Haldar P. K.,
Roy S.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1230
Subject(s) - antipyretic , pharmacognosy , traditional medicine , body weight , yeast , analgesic , chemistry , pharmacology , medicine , biology , biological activity , in vitro , biochemistry
Abstract The methanol extract of the whole plant of Vernonia cinerea (MEVC) was evaluated for its antipyretic potential on normal body temperature and yeast‐induced pyrexia in rats. MEVC signicantly reduced the normal body temperature at doses of 250 and 500 mg/kg body weight p.o. MEVC also lowered the elevated body temperature in the case of yeast‐induced pyrexia in a dose dependent manner. The antipyretic effect of the extract at a dose of 500 mg/kg was identical to that of the standard drug paracetamol. Copyright © 2003 John Wiley & Sons, Ltd.