Premium
First‐trimester genetic diagnosis in multiple pregnancy: Principles and potential pitfalls
Author(s) -
Brambati Bruno,
Tului Lucia,
Lanzani Alessandro,
Simoni Giuseppe,
Travi Maurizio
Publication year - 1991
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970111005
Subject(s) - chorionic villus sampling , amniocentesis , obstetrics , pregnancy , medicine , first trimester , gynecology , prenatal diagnosis , second trimester , gestation , fetus , biology , genetics
Abstract Both the principles of first‐trimester genetic diagnosis in multiple pregnancy and the special considerations required to avoid potential diagnostic pitfalls are presented. The experience consisted of 65 cases of twins and one case of quadruplets. Dichorionic twins were recognized by sonography in 54 cases. Transabdominal aspiration was generally preferred to trans‐cervical for obtaining chorionic tissue, although in two cases both approaches were used. Diagnostic error following erroneous sampling was reported in 3 out of 54 sets of dichorionic twins (5.5 per cent). When like‐sex dichorionic twins cannot be differentiated by cytogenetic or DNA polymorphism studies, amniocentesis should be recommended to confirm the reliability of the result on chorionic tissue.