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Radioguided localization of neuroblastomas in laparoscopic surgery using 123 I‐ radiolabeled metaiodobenzylguanidine
Author(s) -
Hishiki Tomoro,
Saito Takeshi,
Terui Keita,
Mitsunaga Testuya,
Nakata Mitsuyuki,
Hayashi Hideki,
Yoshida Hideo
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25488
Subject(s) - medicine , neuroblastoma , blood cancer , pediatric oncology , laparoscopic surgery , radiology , surgical resection , invasive surgery , chemotherapy , laparoscopy , surgery , cancer , genetics , biology , cell culture
Minimally invasive surgery has become widely recognized and is commonly used for the diagnosis and treatment of neuroblastoma. However, in post‐chemotherapy status or during reoperations, it is occasionally difficult to precisely locate small neuroblastoma lesions, and this becomes prominent in endoscopic surgeries, in which tactile sense is essentially lost. Herein, we report our preliminary experience in two abdominal neuroblastoma cases undergoing laparoscopic tumor resection with aid of intraoperative 123 I‐ metaiodobenzylguanidine (MIBG) radioguidance using a specifically designed gamma‐probe. The procedure enables easier localization of viable neuroblastoma tissue, provided that the tumor shows moderate to high MIBG uptake. Pediatr Blood Cancer 2015;62:1297–1299. © 2015 Wiley Periodicals, Inc.