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Co‐inheritance of mild hemophilia A and heterozygosity for type 2N von Willebrand disease: A diagnostic and therapeutic challenge
Author(s) -
Lindsay Holly,
Bergstrom Katie,
Srivaths Lakshmi
Publication year - 2014
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25054
Subject(s) - von willebrand disease , medicine , loss of heterozygosity , disease , inheritance (genetic algorithm) , blood cancer , phenotype , von willebrand factor , clinical phenotype , pediatrics , immunology , genetics , cancer , platelet , gene , allele , biology
Hemophilia A and von Willebrand disease are the two most common inherited bleeding disorders. Despite their frequency, however, there are very few reports of co‐inheritance of the two disorders. We present the first report of a patient with mild hemophilia A and heterozygosity for type 2N von Willebrand disease (VWD). We discuss the patient's phenotype and highlight the diagnostic and therapeutic challenges caused by this co‐inheritance. Pediatr Blood Cancer 2014; 61:1888–1890. © 2014 Wiley Periodicals, Inc.