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Metachronous manifestations of sweet's syndrome in a neutropenic patient with Fanconi anemia
Author(s) -
ChathamStephens Kevin,
Devere Theresa,
GuzmanCottrill Judith,
Kurre Peter
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21538
Subject(s) - medicine , leukocytosis , pancytopenia , sweet syndrome , dermis , pathology , anemia , parenchyma , pathological , respiratory distress , dermatology , surgery , bone marrow
Abstract Sweet's syndrome (SS) is an acute, febrile neutrophilic dermatosis that frequently presents with leukocytosis and erythematous plaques. Lesions show neutrophilic infiltration of the dermis and rarely other organs. We report the case of an adolescent male with chronic pancytopenia secondary to Fanconi anemia (FA) who presented with acute respiratory distress. Despite an exhaustive and ultimately unrevealing work‐up, the diagnosis of pulmonary SS was not made until he developed characteristic cutaneous lesions 4 months later. Comprehensive review of pathological specimens revealed metachronous SS manifestations with infiltrates in lung parenchyma, dermis, and subcutis in this neutropenic patient. Pediatr Blood Cancer 2008;51:128–130. © 2008 Wiley‐Liss, Inc.