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The relation of cyclic AMP levels to phagocytosis and enzyme release in acute inflammation in vivo
Author(s) -
Deporter D. A.,
Dieppe P. A.,
Glatt M.,
Willoughby D. A.
Publication year - 1977
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711210302
Subject(s) - medicine , medical laboratory , medical school , pathology , medical education
The effect of altering endogenous leucocyte cyclic AMP levels on phagocytosis and lysosomal enzyme release was studied in vivo. Acute pleural exudates were produced in rats using either calcium pyrophosphate dihydrate crystals or rat serum. Despite marked increases in leucocyte cyclic AMP concentration produced by injection of dibutyryl cyclic AMP and theophylline, there was no reduction in crystal phagocytosis or in enzyme discharge.