Photoresponsive hyaluronate nanogel as an anticancer drug carrier | Zendy

Park SoHyun | Zendy; Oh Kyung Taek | Zendy; Kwag Dong Sup | Zendy; Lee Ung Yeol | Zendy; Lee Dong Jin | Zendy; Lee Eun Seong | Zendy

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Photoresponsive hyaluronate nanogel as an anticancer drug carrier

Author(s) -

Park SoHyun,

Oh Kyung Taek,

Kwag Dong Sup,

Lee Ung Yeol,

Lee Dong Jin,

Lee Eun Seong

Publication year - 2013

Publication title -

polymers for advanced technologies

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.61

H-Index - 90

eISSN - 1099-1581

pISSN - 1042-7147

DOI - 10.1002/pat.3143

Subject(s) - nanogel , aqueous solution , biophysics , drug , drug delivery , butyric acid , materials science , combinatorial chemistry , chemistry , nanotechnology , biochemistry , pharmacology , organic chemistry , biology

In this study, we introduced photolabile 4‐(4‐(1‐hydroxyethyl)‐2‐methoxy‐5‐nitrophenoxy)butyric acid (HMNB) to prepare photoresponsive nanogels. Hyaluronate (HA) grafted with 4‐(4‐(1‐hydroxyethyl)‐2‐methoxy‐5‐nitrophenoxy)butyric acid (HA‐ g ‐HMNB) was self organized in aqueous solution. Interestingly, HA‐ g ‐HMNB nanogels exhibited caging and photo‐uncaging properties for an encapsulated antitumor drug. Photoactivation allowed accelerated antitumor drug release from uncaged nanogels. We found a significant improvement in KB tumor‐cell‐killing efficacy when this system was associated with local light irradiation. Copyright © 2013 John Wiley & Sons, Ltd.

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