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Variability of 4D flow parameters when subjected to changes in MRI acquisition parameters using a realistic thoracic aortic phantom
Author(s) -
Montalba Cristian,
Urbina Jesus,
Sotelo Julio,
Andia Marcelo E.,
Tejos Cristian,
Irarrazaval Pablo,
Hurtado Daniel E.,
Valverde Israel,
Uribe Sergio
Publication year - 2018
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.26834
Subject(s) - pulsatile flow , imaging phantom , temporal resolution , image resolution , flow (mathematics) , shear stress , magnetic resonance imaging , flow velocity , phase contrast microscopy , nuclear medicine , biomedical engineering , nuclear magnetic resonance , physics , medicine , mechanics , radiology , optics , cardiology
Purpose To assess the variability of peak flow, mean velocity, stroke volume, and wall shear stress measurements derived from 3D cine phase contrast (4D flow) sequences under different conditions of spatial and temporal resolutions. Methods We performed controlled experiments using a thoracic aortic phantom. The phantom was connected to a pulsatile flow pump, which simulated nine physiological conditions. For each condition, 4D flow data were acquired with different spatial and temporal resolutions. The 2D cine phase contrast and 4D flow data with the highest available spatio‐temporal resolution were considered as a reference for comparison purposes. Results When comparing 4D flow acquisitions (spatial and temporal resolution of 2.0 × 2.0 × 2.0 mm 3 and 40 ms, respectively) with 2D phase‐contrast flow acquisitions, the underestimation of peak flow, mean velocity, and stroke volume were 10.5, 10 and 5%, respectively. However, the calculated wall shear stress showed an underestimation larger than 70% for the former acquisition, with respect to 4D flow, with spatial and temporal resolution of 1.0 × 1.0 × 1.0 mm 3 and 20 ms, respectively. Conclusions Peak flow, mean velocity, and stroke volume from 4D flow data are more sensitive to changes of temporal than spatial resolution, as opposed to wall shear stress, which is more sensitive to changes in spatial resolution. Magn Reson Med 79:1882–1892, 2018. © 2017 International Society for Magnetic Resonance in Medicine.