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Molecular self‐diffusion of intracellular metabolites in rat brain in vivo Investigated by Localized Proton NMR Diffusion Spectroscopy
Author(s) -
Merboldt KlausDietmar,
Hörstermann Dirk,
Hänicke Wolfgang,
Bruhn Harald,
Frahm Jens
Publication year - 1993
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910290123
Subject(s) - in vivo , diffusion , chemistry , proton , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , proton nmr , intracellular , spectroscopy , analytical chemistry (journal) , stereochemistry , chromatography , biochemistry , biology , physics , microbiology and biotechnology , quantum mechanics , thermodynamics
Abstract Molecular self‐diffusion coefficients of water (0.75 ± 0.05), Nacetylaspartate (0.27 ± 0.04), creatines (0.27 ± 0.04), and cholines (0.28 ± 0.08) × 10 −5 cm 2 s −1 were obtained from localized proton NMR spectra of rat brain in vivo using diffusion‐weighted stimulated‐echo (STEAM) sequences with a diffusion time of (Δ − δ/3) = 17 ms.