Molecular self‐diffusion of intracellular metabolites in rat brain  in vivo  Investigated by Localized Proton NMR Diffusion Spectroscopy | Zendy

Merboldt KlausDietmar | Zendy; Hörstermann Dirk | Zendy; Hänicke Wolfgang | Zendy; Bruhn Harald | Zendy; Frahm Jens | Zendy

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Molecular self‐diffusion of intracellular metabolites in rat brain in vivo Investigated by Localized Proton NMR Diffusion Spectroscopy

Author(s) -

Merboldt KlausDietmar,

Hörstermann Dirk,

Hänicke Wolfgang,

Bruhn Harald,

Frahm Jens

Publication year - 1993

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910290123

Subject(s) - in vivo , diffusion , chemistry , proton , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , proton nmr , intracellular , spectroscopy , analytical chemistry (journal) , stereochemistry , chromatography , biochemistry , biology , physics , microbiology and biotechnology , quantum mechanics , thermodynamics

Molecular self‐diffusion coefficients of water (0.75 ± 0.05), Nacetylaspartate (0.27 ± 0.04), creatines (0.27 ± 0.04), and cholines (0.28 ± 0.08) × 10 −5 cm 2 s −1 were obtained from localized proton NMR spectra of rat brain in vivo using diffusion‐weighted stimulated‐echo (STEAM) sequences with a diffusion time of (Δ − δ/3) = 17 ms.

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