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Modulation of autophagy in human diseases strategies to foster strengths and circumvent weaknesses
Author(s) -
Xu Shouping,
Sui Shiyao,
Zhang Xianyu,
Pang Boran,
Wan Lin,
Pang Da
Publication year - 2019
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.21571
Subject(s) - autophagy , intracellular , neuroscience , biology , clinical trial , microbiology and biotechnology , medicine , bioinformatics , apoptosis , biochemistry
Abstract Autophagy is central to the maintenance of intracellular homeostasis across species. Accordingly, autophagy disorders are linked to a variety of diseases from the embryonic stage until death, and the role of autophagy as a therapeutic target has been widely recognized. However, autophagy‐associated therapy for human diseases is still in its infancy and is supported by limited evidence. In this review, we summarize the landscape of autophagy‐associated diseases and current autophagy modulators. Furthermore, we investigate the existing autophagy‐associated clinical trials, analyze the obstacles that limit their progress, offer tactics that may allow barriers to be overcome along the way and then discuss the therapeutic potential of autophagy modulators in clinical applications.