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Dysfunction of Ib (Autogenic) spinal inhibition in patients with progressive supranuclear palsy
Author(s) -
Fine Edward J.,
Hallett Mark,
Litvan Irene,
Tresser Nancy,
Katz David
Publication year - 1998
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870130410
Subject(s) - progressive supranuclear palsy , neuroscience , corticospinal tract , medicine , stimulation , reciprocal inhibition , h reflex , psychology , magnetic resonance imaging , disease , diffusion mri , radiology
Abstract We compared the activity of Ib spinal interneurons in five patients with progressive supranuclear palsy (PSP) with six age‐matched control subjects. Stimulation of the medial gastrocnemius nerve at motor threshold intensity activated Ib afferents that in turn inhibit H reflexes from the soleus muscle. Maximum inhibition occurred at interstimulus intervals of 6 and 8 ms for both control subjects and PSP patients and was significantly greater in the PSP patients. Increased Ib activity of PSP patients may be caused by loss of inhibition of Ib interneurons through degeneration of the medullary reticulospinal pathway. The corticospinal pathways, unopposed by the medullary reticulospinal tract, may excessively activate Ib internurons.