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123I‐FP‐CIT SPECT [(123) I‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)‐N‐(3‐fluoropropyl) nortropane single photon emission computed tomography] Imaging in a p.A53T α‐synuclein Parkinson's disease cohort versus Parkinson's disease
Author(s) -
Koros Christos,
Simitsi Athina,
Prentakis Andreas,
Beratis Ion,
Papadimitriou Dimitra,
Kontaxopoulou Dionysia,
Fragkiadaki Stella,
Papagiannakis Nikolaos,
Seibyl John,
Marek Kenneth,
Papageorgiou Sokratis G.,
Trapali Xenia Geronicola,
Stamelou Maria,
Stefanis Leonidas
Publication year - 2018
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.27451
Subject(s) - putamen , caudate nucleus , parkinson's disease , dopaminergic , medicine , denervation , alpha synuclein , chemistry , pathology , endocrinology , nuclear medicine , gastroenterology , dopamine , disease
ABSTRACT Background: The p.A53T point mutation in the α‐synuclein gene ( SNCA ) is a rare but highly relevant cause of autosomal dominant Parkinson's disease (PD). Objectives: The objective of this study was to assess striatal dopaminergic denervation in a cohort of symptomatic carriers of the p.A53T SNCA mutation as compared to PD patients. Methods: Data from the Parkinson's Progression Markers Initiative database of 11 symptomatic p.A53T SNCA mutation carriers who underwent 123I‐FP‐CIT SPECT [(123) I‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)‐N‐(3‐fluoropropyl) nortropane single photon emission computed tomography] imaging at our site were compared with those of 33 age‐, sex‐, and disease duration–matched PD patients. Results: The p.A53T mutation carriers had significantly lower caudate nucleus binding ratio both contralaterally and ipsilaterally to the most affected side ( P = .002 and P = .006) and a decreased contralateral caudate/putamen signal ratio ( P = .007) as compared to PD. A similar degree of striatal asymmetry was observed in both subgroups. No correlation between scores in neuropsychological tests and caudate nucleus dopaminergic denervation could be demonstrated. Conclusions: PD patients harboring the p.A53T SNCA mutation show evidence of a more severe nigrostriatal denervation, especially evident in the caudate nucleus. The lack of significant differences in the putaminal binding ratios may reflect a floor effect or a true preferential targeting of the caudate terminals in p.A53T SNCA ‐associated PD. © 2018 International Parkinson and Movement Disorder Society