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Application of Modified Bead Cellulose as a Carrier of Active Ingredients
Author(s) -
Volkert Bert,
Wolf Bertram,
Fischer Steffen,
Li Ning,
Lou Chenhua
Publication year - 2009
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200950615
Subject(s) - cellulose , bead , carboxymethyl cellulose , covalent bond , benzocaine , ionic bonding , active ingredient , materials science , chemical engineering , chemistry , organic chemistry , polymer chemistry , chromatography , composite material , sodium , ion , immunology , biology , bioinformatics , engineering
Summary: A new kind of very fine disperse porous bead cellulose is modified by chemical treatments to 2,3‐dialdehyde cellulose, carboxymethyl and dihydrogenphosphate cellulose. Model drugs like benzocaine and prazosin are coupled to these modified bead celluloses by covalent and ionic linkage, respectively and compressed to tablets. Compression mixtures with low loaded benzocaine conjugates release with medium rate. Linkage of prazosin cation to the anionic derivatives of bead cellulose leads to fast release of poor soluble ionic drug.
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