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Phthalocyanine photodynamic therapy: New strategy for closure of choroidal neovascularization
Author(s) -
Kliman Gilbert H.,
Puliafito Carmen A.,
Stern David,
Borirakchanyavat Sidhiporn,
Gregory William A.
Publication year - 1994
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900150103
Subject(s) - photodynamic therapy , neovascularization , choroidal neovascularization , singlet oxygen , irradiation , fluorescence , retina , materials science , chemistry , biomedical engineering , medicine , ophthalmology , retinal , optics , angiogenesis , oxygen , cancer research , physics , organic chemistry , nuclear physics
Abstract Chloro‐aluminum sulfonated phthalocyanine (CASPc) is a photo‐chemically active dye employed in photodynamic therapy (PDT). CASPc is a potent generator of singlet oxygen when irradiated with 675 nm light and is also capable of fluorescence, allowing visualization of the dye in tissues. We devised an angiography system using CASPc fluorescence to determine its localization in experimental choroidal neovascularization in monkeys and then investigated the ability of CASPc to produce photochemical closure of neovascularization upon irradiation with 675nm laser light. Fluorescent imaging indicated that CASPc localized angio‐graphically in areas of neovascularization for at least 24 hours. Irradiation with 675 nm laser light 5–30 minutes after CASPc injection produced complete closure of choroidal neovascularization with minimal damage to overlying retina. We conclude that CASPc localizes in neovascular choroidal vessels and that CASPc photodynamic therapy can produce closure of these choroidal vessels. © 1994 Wiley‐Liss, Inc.