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Carcinogenic and possible mutagenic effects of stilboestrol in offspring exposed in utero
Author(s) -
Bishun N. P.,
Smith N. S.,
Williams D. C.,
Raven R. W.
Publication year - 1977
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930090312
Subject(s) - stilbestrol , diethylstilbestrol , in utero , offspring , medicine , pregnancy , physiology , vagina , vaginal cancer , carcinogen , hormone , cervical cancer , cancer , gynecology , fetus , biology , genetics , surgery
Abstract The relevant literature has been reviewed and it appears that there is no doubt that in utero exposure to stilboestrol is related to the eventual development of vaginal adenocarcinoma in young females. Although cancers of other types are also prevalent, the incidence is not great and may be related to other types of drugs taken during pregnancy. The review attempts to correlate the genetic effects with the abnormal development, but on account of the scarcity of data such correlation is not possible. Further work on the genetic effects and the development of the lower genital tract in the female needs to be carried out.