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MicroRNA‐203 down‐regulation is associated with unfavorable prognosis in human glioma
Author(s) -
He Jianguo,
Deng Yangjia,
Yang Gang,
Xie Wenyi
Publication year - 2013
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23315
Subject(s) - medicine , microrna , glioma , oncology , cancer research , genetics , gene , biology
Abstract Background and Objectives MicroRNA‐203 (miR‐203) serves as a tumor suppressor or a tumor promoter in different human malignancies. However, its involvement in human gliomas is still unclear. The aim of this study was to investigate the clinical significance of miR‐203 expression in gliomas. Methods Real‐time quantitative PCR was employed to measure the expression level of miR‐203 in clinical glioma tissues. Results The expression of miR‐203 was reduced in high WHO grade glioma tissues compared with that in low WHO grade and normal brain tissues, and decreased with ascending tumor WHO grades ( P < 0.001). The reduced miR‐203 expression in gliomas was significantly associated with higher WHO grade ( P < 0.001), lower KPS score ( P = 0.008) and poorer disease‐specific survival of patients ( P = 0.001). More importantly, subgroup analyses according to tumor WHO grade revealed that the disease‐specific survival of patients with low miR‐203 expression in high WHO grades (III–IV) subgroup was significantly shorter than those with high miR‐203 expression ( P < 0.001), but no significant difference was found for patients in WHO grades I–II subgroup ( P = 0.08). Conclusion Our data validate an important clinical significance of miR‐203 in gliomas, and reveal that it might be an intrinsic regulator of tumor progression and a potential prognostic factor for this dismal disease. J. Surg. Oncol. 2013; 108:121–125 . © 2013 Wiley Periodicals, Inc.