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PET probe‐guided surgery
Author(s) -
Gulec Seza A.
Publication year - 2007
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20862
Subject(s) - medicine , medical physics , surgery , general surgery
Abstract Intraoperative localization of PET‐positive recurrent/metastatic lesions can be facilitated using a hand‐held PET probe. PET probe is a high‐energy gamma probe designed to process the 511 keV photons of PET tracers. Intraoperative gamma probe performance is a function of radiopharmaceutical uptake, clearance kinetics, and probe engineering, all determining the target to background ratio (TBR) and detection threshold. A minimum TBR of 1.5:1 is needed in the operative field for the operating surgeon to be comfortable the differences between tumor tissue and normal adjacent tissue are real. Due to high‐energy photon fluxes, achieving a satisfactory TBR intraoperatively is challenging and requires development of a clinically feasible PET‐probe guided surgery protocol. J. Surg. Oncol. 2007;96:353–357. © 2007 Wiley‐Liss, Inc.