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Beneficial effects of Allium sativum L. stem extract on lipid metabolism and antioxidant status in obese mice fed a high‐fat diet
Author(s) -
Kim Inhye,
Kim HaengRan,
Kim JaeHyun,
Om AeSon
Publication year - 2013
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.6094
Subject(s) - allium sativum , endocrinology , medicine , adipose tissue , adiponectin , lipid peroxidation , diet induced obese , lipid metabolism , insulin resistance , white adipose tissue , leptin , obesity , antioxidant , biology , fatty liver , oxidative stress , biochemistry , horticulture , disease
Abstract BACKGROUND This study was designed to examine the potential health benefits of Allium sativum L. (garlic) stem extract ( ASSE ) on obesity and related disorders in high‐fat diet‐induced obese mice. Obese mice were orally administered ASSE at doses of 100, 250 and 500 mg kg −1 body weight day −1 for 4 weeks.RESULTS Consumption of ASSE significantly suppressed body weight gain and white adipose tissue ( WAT ) weight regardless of daily food intake. Obese mice fed ASSE also exhibited a significant decrease in WAT cell size. The decreased level of adiponectin and increased level of leptin in obese mice reverted to near normal mice levels in ASSE ‐treated mice. ASSE administration significantly improved lipid parameters of the serum and liver and inhibited fat accumulation in the liver by modulating the activities of hepatic lipid‐regulating enzymes in obese mice. Administration of ASSE also led to significant increases in antioxidant enzymes and suppressed glutathione depletion and lipid peroxidation in hepatic tissue.CONCLUSION These results suggest that ASSE may ameliorate obesity, insulin resistance and oxidative damage in high‐fat diet‐induced obese mice. © 2013 Society of Chemical Industry