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2‐dodecanol (decyl methyl carbinol) inhibits hyphal formation and SIR2 expression in C. albicans
Author(s) -
Lim Crystale SiewYing,
Wong WonFen,
Rosli Rozita,
Ng KeePeng,
Seow HengFong,
Chong PeiPei
Publication year - 2009
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.200900035
Subject(s) - hypha , candida albicans , dodecanol , yeast , microbiology and biotechnology , chemistry , biology , biochemistry
Candida albicans is capable of undergoing yeast‐hypha transition to attain pathogenicity in humans. In this study, we investigated the differential expression of CaSIR2 via quantitative real‐time PCR (qPCR), during yeast‐hypha transition with and without the presence of 2‐dodecanol. SIR2 transcript levels were found to be significantly enhanced after hyphal induction as compared to the yeast form. This study found that 2‐dodecanol is able to inhibit hyphal development and block SIR2 up‐regulation, even in hyphal‐inducing growth conditions. We suggest that SIR2 may be involved in Candida albicans quorum‐sensing and serum‐induced yeast‐hyphae transition via the Ras1‐cAMP‐Efg1 signalling cascade. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
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